Neuroglobin: an endogenous neuroprotectant
نویسندگان
چکیده
منابع مشابه
Neuroglobin: endogenous neuroprotectant or maintenance of homeostasis?
Neuroglobin: Endogenous Neuroprotectant or Maintenance of Homeostasis? To the Editor: We would like to comment on the latest experimental stroke study in a neuroglobin (Ngb) knock-in mouse by Wang et al1 The intriguing idea that Ngb could act as a reservoir of oxygen, facilitate oxygen transportation or act as a scavenger of reactive oxygen species in the brain has been the main research hypoth...
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Nitric oxide (NO) derived from the inducible isoform of NO synthase (iNOS) is an inflammatory product implicated both in secondary damage and in recovery from brain injury. To address the role of iNOS in experimental traumatic brain injury (TBI), we used 2 paradigms in 2 species. In a model of controlled cortical impact (CCI) with secondary hypoxemia, rats were treated with vehicle or with 1 of...
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Gases such as NO and CO play important roles both in normal physiology and in disease. In recent years, interest has been directed towards other naturally occurring gases, notably H 2 S, which is produced in body by three enzymes namely CBS (cystathionine beta synthase), CSE (cystathionine gamma lyase) and MST (3-Mercaptopyruvate sulfurtransferase), present in mitochondria and/or cytosols where...
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Overstimulation of NMDA-type glutamate receptors is believed to be responsible for neuronal death of the CNS in various disorders, including cerebral and spinal cord ischemia. However, the intrinsic and physiological mechanisms of modulation of these receptors are essentially unknown. Here we report that cholestane-3β,5α,6β-triol (triol), a major metabolite of cholesterol, is an endogenous neur...
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Cell death associated with mitochondrial dysfunction is common in acute neurological disorders and in neurodegenerative diseases. Neuronal apoptosis is regulated by multiple proteins, including neuroglobin, a small heme protein of ancient origin. Neuroglobin is found in high concentration in some neurons, and its high expression has been shown to promote survival of neurons in vitro and to prot...
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ژورنال
عنوان ژورنال: Current Opinion in Pharmacology
سال: 2008
ISSN: 1471-4892
DOI: 10.1016/j.coph.2007.09.003